After two years
research work as a student assistant in Dr. Kezhong
Zhang’s laboratory of the Center for Molecular
Medicine and Genetics, I was given the opportunity
to be a graduate student in the PhD program of the
department. The most attractive characteristic of
CMMG to me is the interdisciplinary environment from
a broad view of translational biomedical research
which allows me to focus on my interest of the
hepatic metabolic syndromes and to explore the
possible treatments for liver diseases.
regulation on the pathogenesis of the association
between metabolic syndromes and liver diseases:
particulate matter-induced hepatic metabolism
dysfunction in a mouse model.
transcriptional factor CREBH regulates hepatic
lipid and glucose hemostasis upon metabolic
place and travel award of the departmental
poster competition in CMMG, 2010
place of the oral presentation session III in
School of Medicine, 2011
- Departmental travel award in CMMG, 2012
- Zheng Z, Xu X, Zhang X, Wang A, Zhang C,
Huttemann M, Grossman LI, et al. Exposure to ambient
particulate matter induces a NASH-like phenotype
and impairs hepatic glucose metabolism in an
animal model. J Hepatol
- Qiu Q, Zheng
Z, Chang L, Zhao YS, Tan C, Dandekar A,
Zhang Z, et al. Toll-like receptor-mediated IRE1alpha
activation as a therapeutic target for
inflammatory arthritis. EMBO J
- Mendez R, Zheng
Z, Fan Z, Rajagopalan S, Sun Q, Zhang
to fine airborne particulate matter induces
macrophage infiltration, unfolded protein
response, and lipid deposition in white adipose
tissue. Am J Transl Res
- Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X,
Dyson G, Williams P, et al. Endoplasmic
reticulum-tethered transcription factor cAMP
responsive element-binding protein, hepatocyte
specific, regulates hepatic lipogenesis, fatty
acid oxidation, and lipolysis upon metabolic
stress in mice. Hepatology
Zhang C, Zhang K. Measurement of ER stress
response and inflammation in the mouse model
of nonalcoholic fatty liver disease.
Methods Enzymol. 2011; 489:329-48.
Zhang C, Zhang K. Role of unfolded protein
response in lipogenesis. World J Hepatol.
2010 Jun 27;2 (6):203-7.
- Lee JS*, Zheng
Z*, Mendez R, Ha SW, Xie Y, Zhang
ER stress induces non-alcoholic steatohepatitis
in an animal model. Toxicol Lett
2012;211:29-38. * Contribute equally.
- Wang G, Liu G, Wang X, Sethi S, Ali-Fehmi R,
Abrams J, Zheng
Z, et al. ERLIN2 promotes breast cancer cell
survival by modulating endoplasmic reticulum
stress pathways. BMC Cancer
Laing S, Wang G,
Briazova T, Zhang C, Wang A, Zheng Z,
Gow A, Chen AF, Rajagopalan S, Chen LC, Sun Q,
Zhang K. Airborne particulate matter
selectively activates endoplasmic reticulum
stress response in the lung and liver tissues.
Am J Physiol Cell Physiol. 2010 Oct;
299(4):C736-49. Epub 2010 Jun 16.