James G. Granneman, PhD

James G. Granneman, PhD
Professor of Molecular Medicine and Genetics and of Internal Medicine
Director, Center for Integrative Metabolic and Endocrine Research (CIMER)
Integrative Biosciences Center, Room 2414
6135 Woodward Avenue
Detroit, MI 48202


University of Massachusetts, PhD, 1981

Research Focus

Adipose tissue cell and molecular biology, target identification and high through-put screening for novel obesity and diabetes therapeutics

Recent Publications

Lee YH, Mottillo EP, Granneman JG. Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta. 2014 Mar;1842(3):358-69. doi: 10.1016/j.bbadis.2013.05.011. Epub 2013 May 17. PubMed PMID: 23688783.

Lee YH, Thacker RI, Hall BE, Kong R, Granneman JG. Exploring the activated adipogenic niche: interactions of macrophages and adipocyte progenitors. Cell Cycle. 2014 Jan 15;13(2):184-90. doi: 10.4161/cc.27647. Epub 2014 Jan 6. PubMed PMID: 24394850; PubMed Central PMCID: PMC3906235.

Mottillo EP, Paul GM, Moore HP, Granneman JG. Use of fluorescence microscopy to probe intracellular lipolysis. Methods Enzymol. 2014;538:263-78. doi: 10.1016/B978-0-12-800280-3.00015-3. PubMed PMID: 24529444.

Donato M, Xu Z, Tomoiaga A, Granneman JG, Mackenzie RG, Bao R, Than NG, Westfall PH, Romero R, Draghici S. Analysis and correction of crosstalk effects in pathway analysis. Genome Res. 2013 Nov;23(11):1885-93. doi: 10.1101/gr.153551.112. Epub 2013 Aug 9. PubMed PMID: 23934932; PubMed Central PMCID: PMC3814888.

Lee YH, Petkova AP, Granneman JG. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 2013 Sep 3;18(3):355-67. doi: 10.1016/j.cmet.2013.08.003. PubMed PMID: 24011071.

Muzik O, Mangner TJ, Leonard WR, Kumar A, Janisse J, Granneman JG. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J Nucl Med. 2013 Apr;54(4):523-31. doi: 10.2967/jnumed.112.111336. Epub 2013 Jan 29. PubMed PMID: 23362317; PubMed Central PMCID: PMC3883579.

Lee YH, Granneman JG. Seeking the source of adipocytes in adult white adipose tissues. Adipocyte. 2012 Oct 1;1(4):230-236. PubMed PMID: 23700537; PubMed Central PMCID: PMC3609101.