Research Interests

The overall theme of the research within my laboratory is the understanding of basic mechanisms of molecular and cellular biology that are altered as cells progress to become neoplastic. My approach has been to use in vitro human cell models of carcinogenesis and differentiation to identify critical molecular mechanisms. We have identified studied spontaneous genomic instability immortalization in cells from familial cancer patients. In particular we are interested in mechanisms of transcription that cause changes in cell phenotype. We are developing novel cancer diagnostics methods for high risk populations who are genetically predisposed to cancer.

Selected Publications

Fridman, A.L., Tang, L., Kulaeva, O.I., Ye, B., Li, Q., Nahhas, F., Land, S.J., Roberts, P.C., Abrams, J., and Tainsky, M.A. Expression Profiling Identifies Three Pathways Altered in Cellular Immortalization: Interferon, Cell Cycle and Cytoskeleton. J Gerontol A Biol Sci Med Sci. 2006, 61:879-89.

Dilworth, J.T., Kraniak, J.M., Wojtkowiak, J.W., Gibbs, R.A., Borch, R.F., Tainsky, M.A., Reiners, J.J. Jr, Mattingly, R.R. Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1. Biochem Pharmacol. 2006, 72:1485-92.

Southwood, C.M., Peppi, M., Dryden, S., Tainsky, M.A., Gow, A. Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System. Neurochem Res. 2007 32:187-195.

Nahhas, F., Dryden, S.C., Abrams, J., and Tainsky, M.A. Phosphorylation of SIRT2 Deacetylases Does not Regulate its Interaction with HDAC6 and Tubulin, Molecular and Cellular Biochemistry, 2007, 303: 221-30.

Lin, H.S., Talwar, H.S., Tarca, A., lonan, A., Chatterjee, M., Ye, B., Wojciechowski, J., Mohapatra, S., Basson, M.D., Yoo, G., Peshek, B., Lonardo, F., Pan, C.J., Draghici, S., Abram, J., Tainsky, M.A. Proteomic approach for serum-based detection of head and neck cancer. Cancer Epidemiology, Biomarkers and Prevention, 2007; 162396-2405.

Li, Q., Tang, L., Roberts, P.C., Kraniak, J.M., Fridman, A., Kumaeva, O., Tehrani, O., and Tainsky, M.A. Interferon Regulatory Factors Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts. Molecular Cancer Research, 2008, 5:770-84.

Fridman, A.L., and Tainsky, M.A. (2008). Critical Pathways in Cellular Senescence and Immortalization Revealed by Gene Expression Profiling. Oncogene, 2008. 27:5975-87.

See also: http://www.karmanos.org/~tainskym/