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WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE



MOLECULAR AND TRANSLATIONAL NEUROLOGY LABORATORY

PUBLICATIONS:

Basic Neuroscience Publications:

Li Q, Loeb JA (2001) Neuregulin-HSPG interactions produce sustained ErbB receptor activation required for the induction of AChRs in muscle. J Biol. Chem. 276:38068-38075.

Loeb JA, Hmadcha A, Fischbach GD, Land SJ, and Zakarian VL (2002) Neuregulin Expression at Neuromuscular Synapses is Modulated by Synaptic Activity and Neurotrophic Factors, J.  Neurosci. 22:2206-2214.

Loeb JA (2003) Neuregulin: An Activity-Dependent Synaptic Modulator at the Neuromuscular Junction. J Neurocytol. 32:649-664.

Li Q, Esper RM, and Loeb JA (2004) Synergistic Effects of Neuregulin and Agrin on Muscle Acetylcholine Receptor Expression. Mol. Cell. Neurosci. 26:558-69.

Esper RM and Loeb JA (2004) Rapid axoglial signaling mediated by neuregulin and neurotrophic factors.  J. Neurosci. 24:6218-27.

Yao B, Rakhade SN, Li Q, Ahmed A, Krauss R, Draghici S, and Loeb JA (2004) Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cells BMC Bioinformatics 2004, 5:99

Li Q, Ahmed S, and Loeb JA (2004) Development of a proliferative autocrine neuregulin signaling loop during the malignant transformation of human breast epithelial cells. Cancer Research 64:7078-85

Pankonin MS, Gallagher JT, Loeb JA. (2005) Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling.. J Biol Chem. 280(1):383-8.

Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, Salzer JL. (2005) Neuregulin-1 type III determines the ensheathment fate of axons. . Neuron. 47(5):681-94.

Rakhade SN, Yao B, Ahmed S, Asano E, Beaumont TL, Shah AK, Draghici S, Krauss R, Chugani HT, Sood S, Loeb JA.. (2005) A common pattern of persistent gene activation in human neocortical epileptic foci. Ann Neurol. 58(5):736-47.

Hapner SJ, Nielsen KM, Chaverra M, Esper RM, Loeb JA, Lefcort F (2006) NT-3 and CNTF exert pleiotropic effects in the immature dorsal root ganglion including neuregulin-mediated proliferation of progenitor cells and neuronal differentiation. Dev. Biol. 297(1):182-97.

Esper RM, Pankonin, MS, Loeb JA (2006) Neuregulins: Versatile growth and differentiation factors in nervous system development and human disease, Brain Res. Rev. , 51:161-75.

Loeb JA (2007) Neuroprotection and repair by neurotrophic and gliotrophic factors in multiple sclerosis, Neurology 68;38-42..

Rakhade SN, Shah AK, Agarwal R, Yao B, Asano E, and Loeb JA  (2007)  Activity-dependent Gene Expression Correlates with Interictal Spiking in Human Neocortical Epilepsy. Epilepsia 48 Suppl 5:86-95. Erratum in: Epilepsia. 2007 Dec;48(12):2380.

Rakhade SN and Loeb JA (2008) Focal reduction of neuronal glutamate transporters in human neocortical epilepsy, Epilepsia, Feb;49(2):226-36. Epub 2007 Sep 12.

Pankonin MS, Kamholz J, Sohi J and Loeb JA.  (2009) Differential Distribution of Neuregulin in Human Brain and Spinal Fluid Brain Res, 1258, 1-11.

Barkmeier DT, Loeb JA. (2009) An animal model to study the clinical significance of interictal spiking.. Clin. EEG Neurosci , 40, 234-238.

Esper RM and Loeb JA.  (2009) Neurotrophin Activation of Protein Kinase C Delta Induces Neuregulin Release from Neurons.  J. Biol. Chem. 284(39):26251-60..

Ma Z, Li Q, An, H, Pankonin MS, Loeb JA.  (2009) Targeting Her2 Signaling with Neuregulin's Heparin-Binding Domain  J. Biol. Chem. 284(46):32108-15.

De Guzman RC, Loeb JA, VandeVord PJ (2010) Electrospinning of matrigel to deposit a basal lamina-like nanofiber surface. J. Biomat.Sci. 21: 1081-1101.

Calvo M, Zhu N, Tsantoulas C, Ma A, Grist J, Loeb JA, Bennett DLH. (2010) Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. J. Neurosci. 14:5437-50.
   
Loeb JA. (2010) A human systems biology approach to discover new drug targets in epilepsy. Epilepsia 51 (Suppl.3): 171-177.

Calvo M, Zhu N, Grist J, Ma Z, Loeb JA, Bennett DLH (2011) Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway. Glia 59(4):554-68.

Loeb JA. (2011)  Identifying targets for preventing epilepsy using systems biology.  Neurosci Lett. 497(3):205-12

Ma Z, Wang J, Song F, Loeb JA. (2011)   Critical period of axoglial signaling between neuregulin-1 and brain-derived neurotrophic factor required for early Schwann cell survival and differentiation.
J Neurosci. 31(26):9630-40.

John J, Li Y, Ahang J, Loeb JA, Xu Y (2011) Microfabrication of 3d neural probes with combined electrical and chemical interfaces. J. Micromech. Microeng. 21 (2011) 105011.

Song F, Chiang P, Wang J,  Ma Z, Ravits, J,  Loeb JA. (2012) Abberant neuregulin 1 signaling in amyotrophic lateral sclerosis. J Neuropath Exp Neurol, 71:104-15.

Barkmeier DT,, Senador D, Leclercq K, Pai D, Hua J, Boutros NN, Kaminski RM, Loeb JA. (2012)  Electrical, Molecular and Behavioral Consequences of the Interictal Epileptic State in the Rat,  Neurobiol Disease, 47(1):92-101.

Beaumont TL, Yao B, Shah A, Kapatos G, Loeb JA. (2012) Layer-Specific CREB target gene induction in human neocortical epilepsy,  J Neurosci, 32(41):14389-14401.

Lipovich L, Dachet F, Bagla S, Balan K, Cai J, Jia H, Loeb JA, (2012) Activity-dependent human brain coding / non-coding gene regulatory networks,   Genetics, (in press).



Clinical Neuroscience Publications:

Loeb JA (1998) Functional improvement in a patient with basal ganglia calcification using a bisphosphonate.  Movement disorders 13:345-349.

Loeb JA (1998) Features of Leao's spreading depression in patients with lesions near sensory cortex. J. Epilepsy 11:110-115.

Loeb JA (2002) Recertification for neurologists, (Post publication peer review; letter to the editor) Neurology (on-line).

Li J, Loeb JA, Shy ME, Shah AK, Tselis AC, Kupski WJ, and Lewis RA (2003) Asymmetric flaccid paralysis: A neuromuscular presentation of West Nile virus infection.  Ann. Neurol. 53:703-10.

Nash TE, Del Brutto OH, Butman JA, Corona T, Delgado-Escueta A, duron R, Evans CAW, Gilman RH, Gonzalez AE, Loeb JA, Medina MT, Pietch-Escueta S, Pretell EJ, Takayanagui OM, Theodore W, Tsang VCW, Garcia HH (2004) Calcific neurocysticercosis and epileptogenesis. Neurology  62: 1934-38.

Maslinksi PG an d Loeb JA (2004) Pica-Associated Cerebral Edema in an Adult. J Neurol. Sci 225:149-151. 

Loeb JA, Sohrab SA, Huq M, Fuerst, D (2006) Brain calcifications induce neurological dysfunction that can be reversed by a bone drug J. Neurol. Sci. 243:77-81.

TE. Nash, G Singh, AC White, V Rajshekhar, JA Loeb, JV  Proaño, OM Takayanagui, AE Gonzalez, JA Butman, C DeGiorgio, OH. Del Brutto, A Delgado-Escueta, CAW Evans, RH Gilman, SM Martinez, MT Medina,  J Pretell,  J Teale, HH. Garcia (2006) Treatment of Neurocysticercosis - Current Status and Future Research Needs. Neurology, 67(7):1120-7.

Shah AK, Agarwal R, Carhupoma JR, Loeb JA (2006) Compressed EEG pattern analysis for critically ill neurological-neurosurgical patients.  Neurocritical Care 5(2):124-33.

Yadav R, Shah AK, Loeb JA, Swamy MNS, Agarwal R (2011) A Novel Unsupervised Spike Sorting Algorithm for Intracranial EEG. Conf Proc IEEE Eng Med Biol Soc.  2011:7545-8.

Barkmeier DT, Agarwal R, Atkinson M, Flanagan D, Shah AK, Jafari-Khouzani K, and Loeb JA,  (2012) High inter-reviewer variability of spike detection on intracranial EEG addressed by an automated multi-channel algorithm,  Clin Neurophysiol, 123(6):1088-95.

Yadav R, Shah AK, Loeb JA, Swamy MNS, Agarwal R (2012) Morphology-based Automatic Seizure Detector for Intracerebral EEG Recordings. IEEE Trans Biomed Eng, 59(7):1871-81.

Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H (2012) Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design, Epilepsia, (in press).

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